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Erectile Dysfunction Blue Dot Tadalafil-20 mg ( Cialis)

 Cialis Tadalafil-20mg

What is Tadalafil (Cialis)?

Tadalafil (Cialis) is the third oral medicine approved by the United FDA in the US for the treatment of erectile dysfunction. Like Sildenafil (Viagra) and Vardenafil (Levitra), Tadalafil inhibits PDE5.

How effective is Tadalafil (Cialis)?

The safety and efficacy of tadalafil in the treatment of erectile dysfunction was evaluated in numerous clinical trials involving more than 4,000 men.

In these trials, tadalafil was significantly better than placebo in improving men's ability to achieve and maintain erections. Improvements in erectile function was observed in some patients at 30 minutes after taking a dose; and improvements can last for up to 36 hours after taking Cialis when compared to placebo.

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How should Tadalafil (Cialis) be administered?

The recommended starting dose of tadalafil for most patients is 10 mg taken orally approximately 1 hour before sexual activity. The dose may be adjusted higher to 20 mg or lower to 5 mg depending on efficacy and tolerability. The maximum recommended dosing frequency is once per day, although for many patients tadalafil can be taken less frequently since the improvement in erectile function may last 36 hours. Tadalafil may be taken with or without food.

What are the side effects of Tadalafil?

Tadalafil is generally well tolerated with only mild side effects. The most common side effects reported include headache, indigestion, back pain, muscle aches, facial flushing, and nasal congestion.

Back pain and muscle aches occurred in less than 7% of patients, and usually occurred at 12 to 24 hours after taking tadalafil. The back pain and muscle aches associated with tadalafil were characterized by mild to moderate muscle discomfort in the lower back, buttocks and thighs, often aggravated by lying down. The back and muscle aches resolved in most patients without treatment within 48 hours. When treatment was necessary, acetaminophen (Tylenol) and non-steroidal antiinflammatory drugs (NSAIDs) such as Motrin, Advil, or Aleve were effective. Approximately 0.5% of all the patients using tadalafil discontinued the drug due to back pain or muscle aches.

Reports of abnormal vision were rare, it occurred in less than 0.1% of patients using tadalafil.

There have been rare reports of priapism (prolonged and painful erections lasting more than 6 hours) with the use of oral PDE5 inhibitors such as vardenafil, sildenafil and tadalafil. Patients with blood cell diseases such as sickle cell anemia, leukemia, and multiple myeloma have higher than normal risks of developing priapism. Priapism untreated can cause injury to the penile tissue and lead to permanent loss of potency. If there is prolonged erection (longer than 4 hours), immediate medical assistance should be sought.

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Who should not use Tadalafil ?

Tadalafil can cause hypotension (abnormally low blood pressure, which can lead to fainting and even shock) when given to patients who are taking nitrates. Patients taking nitrates daily, even patients taking nitrates only once a day, should not take tadalafil. Most commonly used nitrates are medications to relieve angina (chest pain due to insufficient blood supply to heart muscle because of narrowing of the coronary arteries). These include nitroglycerine tablets, patches, ointments, sprays, pastes, and isosorbide dinitrate and isosorbide mononitrate. Other nitrates such as amyl nitrate and butyl nitrate are found in some recreational drugs called "poppers".

Tadalafil should not be used with alpha-blockers (except Flomax), medicines used to treat high blood pressure and benign prostate hypertrophy (BPH), because the combination of tadalafil and an alpha-blocker may lower the blood pressure greatly and lead to dizziness and fainting. Examples of alpha-blockers include tamsulosin (Flomax), terazosin (Hytrin), doxazosin (Cardura), alfuzosin (Uroxatrol), and prazosin (Minipress). The only alpha-blocker that can be used safely with tadalafil is tamsulosin (Flomax). When tadalafil (20 mg) was given to healthy men taking 0.4 mg of Flomax daily, there was no significant decrease in blood pressure and so patients on this dose of tamsulosin (Flomax) can be prescribed tadalafil.

Tadalafil is not recommended for men with the following conditions:

Unstable angina (chest pain due to coronary artery disease that occurs at rest or with minimal physical exertion)

Low blood pressure (a resting systolic blood pressure less than 90mm Hg)

Uncontrolled high blood pressure (greater than 170/110 mm Hg)

Recent stroke or heart attack (within 6 months)

Uncontrolled, potentially life-threatening abnormal heart rhythms

Severe liver disease

Severe heart failure or disease of the heart's valves, for example, aortic stenosis

Retinitis pigmentosa

Therefore, men with these conditions should not use tadalafil without having these conditions evaluated and stabilized first. When there is angina or heart failure, the doctor may need to determine whether the heart has enough reserve to safely carry out the work necessary for sexual activity by performing cardiac treadmill stress testing.

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What precautions should be taken when using Tadalafil?

In most healthy men, some of the drug will remain in the body for more than 2 days after a single dose of tadalafil. Metabolism (clearing of the drug from the body) of tadalafil can be slowed by liver disease, kidney disease, and concurrent use of certain medications (such as erythromycin, ketoconazole, and protease inhibitors).

Slowed breakdown allows tadalafil to stay in the body longer and potentially increase the risk for side effects. Therefore, the dose and frequency of tadalafil has to be lowered in the following examples:

Medications such as erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), ritonavir (Norvir), and indinavir (Crixivan) can slow the breakdown of tadalafil. Therefore men taking these medications should not take more than 10 mg of tadalafil and should not take tadalafil more frequently than every 72 hours.

No Tadalafil dose adjustment is necessary for men with only mild kidney disease. Men with moderately severe kidney impairment should start tadalafil at 5 mg every 24 hours, and not to exceed the maximum dose of 10 mg taken every 48 hours. In men with severe kidney disease and on dialysis, the maximum dose should not exceed 5 mg.

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Disclaimer

The information contained herin is a summary and does not contain all possible information about this product / products. For complete information about this product / products or your specific health needs, ask your health care professional. Always seek the advice of your health care professional if you have any questions about this produ t/ products or your medical condition.

This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your health care professional. This information does not contain any assurances that this product / products is safe, effective, or appropriate for you.

 

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